Chase-Topping et al. report in the current issue of Emerging Infectious Disease that Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections.

To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk.

However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition.

The complete report is available at http://wwwnc.cdc.gov/eid/article/18/3/11-1236_article.htm.

A 5-year-old girl remains hospitalized in the Louisiana Health Sciences Center-Shreveport's pediatric intensive care unit more than two weeks after contracting E. coli O157 while attending a party in Richland Parish.

Tom Sumrall, the girl's grandfather, said as many as 15 children were sickened following an end-of-the-year Ouachita Christian School party last month on a farm between Start and Rayville.

OCS headmaster Bobby Stokes said the party was not put on by the school.

At least three children were hospitalized. A young boy was released from a Jackson, Miss., hospital last week and a young girl was released from LSU Health Sciences Center-Shreveport Thursday, Sumrall said.

Dr. Shelley Jones, the Louisiana Department of Health and Hospitals Region 8 director, suspects the children contracted the E. coli while playing in a mud pit. It was likely transmitted from the infected fecal matter of a cow.

"We do know based on preliminary analysis that the children who played in the mud pit more than five minutes were more likely to have symptoms," Jones said.

"But the state lab is unable to do environmental testing, so we're probably not going to know definitively."

John Cooper, the 5-year-old girl's father, said his daughter remains on dialysis and was just removed from a venilator on Thursday. Cooper said both of his daughter's lungs collapsed.

Every time some government type says there are more cases of E. coli O157:H7 and other dangerous bacteria in the summertime because people barbeque more, I cringe. It’s one of those blame-the-consumer comments when the reality is more complicated. 

Most food safety interventions are designed to reduce or eliminate pathogen loads – to lower the number of harmful bugs from farm-to-fork. A piece of highly-contaminated meat can wreck cross-contamination havoc in a food service or home kitchen.

Elizabeth Weise writes in USA Today today that animals carry higher levels of E. coli O157:H7 and friends during the summer months, and summarizes efforts to lower bacterial loads on animals entering slaughter plants.

Jerold Mande, USDA deputy undersecretary for food safety, said last month,

"To take the next big step forward on food safety, we need to do more to have fewer pathogens on food animals when they arrive at the slaughterhouse gate.”

Jim Marsden of Kansas State University said that microbiologically, the biggest "bang for the buck" is cleaning the bacteria off the hide or the carcass to keep it from coming into contact with the meat.

Weise writes that a number of possible interventions are in the works. Each, it is hoped, might take down the incidence of E. coli O157:H7 by a factor of 100. Below is the edited list.

Vaccines: Gut warfare

Probably the most hopeful are vaccines that lower the amount of O157:H7 in cattle's guts. Two are furthest along, one from a Minnesota company called Epitopix and one by a Canadian company called Bioniche Life Sciences. Epitopix's vaccine has received preliminary approval from the USDA and is being tested in the USA. Bioniche's vaccine was approved in Canada last year and is in the approval process in the USA. In addition, scientists at the USDA's National Animal Disease Center in Ames, Iowa, have developed two more vaccines.

Field trials of the Epitopix vaccine showed that 86% of vaccinated cattle stopped shedding O157:H7 bacteria in their feces. Of those that still were shedding bacteria, there was a 98% reduction in the amount, says Daniel Thomson (left, photo from USA Today), a veterinarian and professor of Production Medicine at Kansas State University in Manhattan, Kan., who has studied the effectiveness of vaccine for the company.

The issue for cattlemen will be the costs of the two or three shots necessary to create immunity and the wear and tear on the cattle caused by bringing them in to be vaccinated. Going through the chute that holds them still while they're given the shot, necessary to safeguard workers, can cause some cattle to become agitated.

Phages: A spray of bacteria fighters

Cattle walking through a car-wash-like spray of bacteria-eating viruses called phages sounds more science fiction than feedlot, but it's actually in use across the USA. In cattle, a phage that is specific to E. coli O157:H7 is sprayed on the animals one to four hours before they're slaughtered. "They like to have them soak," says Dan Schaefer, director of beef research and development at in Wichita. Cargill is testing the spray at one of its plants.

Probiotics: 'Exclusion' cultures

Basically these are bacterial cultures much like those in yogurt, given to cattle in their feed. They're called "competitive exclusion" cultures because they out-compete the bad bacteria and exclude them in the animals' guts. Michael Doyle, director of the Center for Food Safety at the University of Georgia in Griffin, spent years investigating them.

One for E. coli O157:H7 "worked really well for a while and then it stopped working for a while," he says. Doses required are often higher than those claimed by the companies that sell them, he says. Currently these aren't approved by USDA or FDA as E. coli reduction methods, so the companies that market them can't make any specific claims for them.

Sodium chlorate: A 'suicide pill'

This chemical is used in part to do environmentally safe paper bleaching. But administered in extremely small amounts, it also plays a deadly trick on E. coli O157:H7 and salmonella.

In the oxygen-free environment of a cow's gut, these bacteria are able to obtain energy from nitrogen. But they can't tell the difference between nitrogen and chlorate, so if there's chlorate present, they try to use that. This turns the chlorate into bleach, killing the bacteria from the inside without harming the animal.

Grain vs. high-quality hay

Research in Texas, Kansas and Idaho has shown that switching cattle from grain to a more expensive diet of high quality hay before slaughter may lower E. coli O157:H7 rates, though the findings have not always been consistent.

From an epidemiologic standpoint, it's clear that these pre-slaughter interventions lower the E. coli O157:H7 burden in the cattle, says Guy Loneragan, a professor of animal science and expert in O157:H7 in cattle at West Texas A&M University in Canyon, Texas.

The question is whether investing money on the ranch and feedlot will save money at the packing plant.

Cows can be dangerous.

The U.S. Centers for Disease Control reported last week that from 2003-2007, cattle were the primary or secondary cause of death for 108 people.

During the same period, Iowa, Kansas, Missouri, and Nebraska accounted for 16% of the nation's approximately 985,000 cattle operations and 21% of the nation's cattle and calf herd.

To better characterize cattle-caused deaths in these four states, investigators reviewed all such deaths occurring during the period 2003--2008 that were detected by two surveillance programs, the Iowa Fatality Assessment and Control Evaluation (IA FACE) and the Great Plains Center for Agricultural Health (GPCAH). This report summarizes that investigation, which identified 21 cattle-related deaths. These deaths occurred throughout the year, and decedents tended to be older (aged ≥60 years) (67%) and male (95%). Except in one case, the cause of death was blunt force trauma to the head or chest. Circumstances associated with these deaths included working with cattle in enclosed areas (33%), moving or herding cattle (24%), loading (14%), and feeding (14%). One third of the deaths were caused by animals that had previously exhibited aggressive behavior.

To reduce the risk for death from cattle-caused injuries, farmers and ranchers should be aware of and follow recommended practices for safe livestock-handling facilities and proper precautions for working with cattle, especially cattle that have exhibited aggressiveness.